Peripheral giant cell granuloma or the socalled giant cell epulis is the most common oral giant cell lesion. Central giant cell granuloma was 1st described in jaws by jaffe 1953. It normally presents as a soft tissue purplishred nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. Giant cell tumor of the temporal bone a case report. Peripheral giant cell granuloma pubmed central pmc. Radiographs of a biopsyproven central giant cell granuloma of the left anterior mandible in a 23yearold female a represents the lesion at the time of biopsy and. Revisiting the role of the granuloma in tuberculosis. In 1980, only cases of this entity had been described. Giant cell reparative granuloma, central definition of. Treatment of central giant cell granuloma of the jaw with calcitonin.
Epithelioid cells can be highly phagocytic but in some cases do not contain bacteria at all. The central giant cell granuloma is an uncommon lesion only seen in the toothbearing regions of the jaws, most commonly in the mandible and typically in the second and third decades. The patient followed up 3 months after the surgery. Peripheral giantcell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. It is a noncancerous condition that is usually painless, but irritation and open lesions in the mouth can lead. Central giant cell granuloma of the jaws springerlink. Central giant cell granuloma, benign jaw tumor, molar, recurrent pericoronitis, multinucleated giant cells. Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity. It is often difficult to make a clinical diagnosis.
From the files of the oral pathology laboratory at. Although central giant cell granulomas cgcgs appear to be benign, their radiographic findings are active. Giant cell carcinoma of the lung is an unusual form of pulmonary malignancy that follows an extremely aggressive clinical course. Aorthopantomogramshowed a heterogeneous bone structure of the mandible fig. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made. Giant cell reactions giant cell reparative granulomas are uncommon lesions that predominantly involve the small bones of the hands and feet. The central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in toothbearing areas. These granulomas occur in the jaws and have giant cells as. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the. The peripheral giant cell granuloma, also known as giant cell epulis, pgcl or giant cell hyperplasia, is the most common giant cell lesion in the oral cavity. It may exhibit aggressive biologic behavior, characterized by localized swelling, pain, rapid growth, bony expansion, cortical perforation, tooth displacement, and root resorption.
Radiological and epidemiological aspects of central giant cell. We present an unusual case of a giant cell reparative granuloma arising from the left temporal lobe area of a 38yearold man and provide clinical and mr findings. Formerly called giant cell reparative granuloma giant cell lesion primarily of jaw, also other craniofacial bones and short tubular bones of hands and feet may be response to injury but some. Case report giant cell reparative granuloma of temporal. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg.
Central giant cell granuloma of the jaw is considered a nonneoplastic lesion. Aneurysmal bone cyst and other giant cell lesions of the jaws. Intracranial giant cell reparative granuloma arising from. Central giant cell granuloma is a benign lesion of the jaws which is sometimes aggressive locally. Pdf central giant cell granuloma is an uncommon, benign, and proliferative lesion whose etiology is not defined. Multifocal central giant cell granuloma a case report ncbi. A giant cell fibroma, a type of fibrous hyperplasia, was discovered during a preventive patient visit in.
It was first described as central giant cell reparative granuloma by jaffe h l in the year 1953. Giant cell granuloma definition of giant cell granuloma. We report the clinical and roentgenographic manifestations of 14 patients. The radiologic features of central giant cell granuloma cgcg have not been clearly defined, and conflicting. Giant cell granuloma an overview sciencedirect topics. Granuloma with central necrosis in a lung of a person with tuberculosis. Giant cell reparative granuloma of the mandible discussion giant cell reparative granuloma is an uncommon lesion that is a reactive process and not a neoplasm. The petrous portion of the temporal bone forms a rare location for this tumor. Note the langhanstype giant cells with many nuclei arranged in a horseshoelike pattern at the edge of the cell around the. They result from a local inflammatory process, thought to be secondary to trauma.
The peripheral giant cell granuloma pgcg was first described by jaffe in 1953. The aim of this study was to determined demographic, clinical and radiographic features of central giant cell granuloma cgcg of the jaws, for the first time, in north east iran. Annular elastolytic giant cell granuloma is a histiocytic granulomatous dermal infiltrate that results in phagocytosis and destruction of elastic fibres. Giant cell reaction giant cell reparative granuloma of. Earlier, it was called giant cell reparative granuloma, a misnomer, or even giant cell lesion. Various other benign soft tissue lesions need to be differentiated. Extremely aggressive behavior of central giant cell. Discussion jaffe initially described the term reparative gccg to. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown etiology. These tumors become severely invasive with the stimulus of surgery, resembling. It normally presents as a soft tissue purplishred nodule consisting of multinucleated giant cells. It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in. The appearance is generally distinctive with multinucleated giant cells. Giant cell reparative granuloma gcrg is an uncommon and nonneoplastic reactive tumor that involves the maxilla and mandible in the region of the head and neck.
Article information, pdf download for central giant cell granuloma of the. Pdf on jun 7, 2019, nilotpol kashyap and others published central giant cell granuloma find, read and cite all the research you need on. This group of lesions includes central giant cell granuloma cgcg, giant cell tumor of long bones, aneurysmatic bone cyst, brown tumor of hyperparathyroidism. Granuloma annulare ga can be seen in both genders and all ppt. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long. The recurrence rate for pyogenic granuloma is said to be 16% of the treated lesions and so reexcision of such lesions might be necessary 8. Central giant cell granuloma cgcg of the jaw is a benign osteolytic lesion. Medical school giant cell temporal arteritis made easy duration. The diagnosis and management of giant cell lesions of the jaws.
The true nature of these lesions is unknown but, as they are invariably destructive, the term reparative giant cell granuloma would. An analysis of peripheral giant cell granuloma associated with dental. Central giant cell granuloma cgcg is relatively an uncommon central bony lesion in the head and neck region, commonly affecting the jaw. Occurrence of a pyogenic granuloma in relation to a dental. Annular elastolytic giant cell granuloma pathology. Aggressive variant of central giant cell granuloma austin. It does not constitute a true neoplasm, but rather a. Because of its overwhelming incidence on the gingiva. The most common treatment is curettage,which has a high recurrence rate, particularly in more.
Calcitonin therapy in central giant cell granuloma of the jaw. Giant cell granulomas are benign intraosseous lesions, typically occurring in young females. The diagnosis and management of giant cell lesions of the jaws ncbi. Pyogenic granuloma hyperplastic lesion of the gingiva. Giant cells in health and disease issn24555592 international journal of community health and medical research vol.
Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. The peripheral giant cell granuloma has an unknown etiology, with some dispute as to whether this lesion represents a reactive or neoplastic process. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad. A central giant cell granuloma is a type of bone lesion that appears along the jaw. The journal of the american dental association, 492, 141148. Granuloma annulare ga can be seen in both genders and all age groups, but is most commonly seen in females. It will attempt to point out the differences between these lesions and giant cell lesions elsewhere in the body and also the current techniques for. Radiologic features of central giant cell granuloma. Three patients with similar giant cell reactions were identified from the mayo clinic files, and an additional 27 patients were collected from the consultation files of one of the authors. Diagnosis of central giant cell granuloma is normally made histologically from an incisional biopsy. Giant cell reparative granuloma, temporal bone, magnetic resonance imaging introduction giant cell reparative granuloma is a rare disease with variable behaviors and clinical presentations. Peripheral giant cell granuloma or so called giant cell epulis is the most common oral giant cell lesion. Central giant cell granuloma is a benign intraosseous lesion of the jaws. Giantcell reparative granuloma, traumatic bone cyst, and fibrous.
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